Reduced dopamine concentrations in the prefrontal cortex are thought to contribute to attention deficit disorder and negative schizophrenia... Dopamine is a neurotransmitter that is involved in depression. Amphetamines and dopamine reuptake blockers have potent anti-depressant effects but these drugs quickly lose their benefit after they deplete dopamine levels in the brain. http://en.wikipedia.org/wiki/Dopamine#Biochemistry
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